Molecular understanding of KRAS- and BRAF - DiVA Portal

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Tumörmikromiljö - Forskningsoutput - Lunds universitet

PloS one 8, e85353 (2013). 201. Li, T., Luo  Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly SATB2 in Combination With Cytokeratin 20 Identifies Over 95% of all  Testföremål inkluderade Osteocalcin, Osteonectin, Osteopontin, Vim, S-100, Actin, SMA, CK, NSE, CD99, SATB2, MDM2, CDK4, Ki67 och P53, men alla  Value of SATB2 Immunostaining in the Distinction Between Small Intestinal and CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-induced Apoptosis Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B2013Ingår i: Genome Biology, ISSN  Analysis of transcript and protein overlap in a human osteosarcoma cell line2010Ingår i: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 11, nr 1, s. Promotes Viability and Inhibits Apoptosis of Osteosarcoma Cells by Activating Value of SATB2 Immunostaining in the Distinction Between Small Intestinal  inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells.

Satb2 osteosarcoma

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Conclusions: SATB2 is a sensitive marker for osteosarcoma; however, it is not specific, with expression being observed in other high-grade primary bone sarcomas. SATB2 was a very sensitive marker for osteosarcoma: 100% on whole slides, and 94%, including tissue micro-array (TMA) data, as reported by David and Horvai. These results are also analogous to the findings published previously by Connor and Hornick, who report a 98% sensitivity of this marker for staining osteosarcomas. SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for osteosarcoma patients. Conclusion: SATB2 is a reliable osteoblastic marker for differential diagnosis of osteosarcoma and non-osteoid sarcoma, although with a limited role in separating osteosarcoma from non-malignant osteoblastic lesions.

SATB2-AS1 expression was significantly higher in the metastatic tumors compared to non-metastatic tumors. 1. SATB2 enhances migration and invasion in osteosarcoma.

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• Undifferentiated pleo. sarcoma (bone).

Satb2 osteosarcoma

Tumörmikromiljö - Forskningsoutput - Lunds universitet

Satb2 osteosarcoma

SATB2 is commonly expressed in osteosarcomas.

The sphere for- mation assay,  SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma  In the present study, we describe the expression profile of lncRNAs in osteosarcomas compared with paired adjacent non-cancerous tissue (n=7) using microarray  Histochemical staining of alkaline phosphatase can demonstrate the osteoblastic nature of the tumor. Novel immunohistochemical markers SATB2 and DMP1  May 6, 2020 For example, SATB2 overexpression increased cell proliferation, stem cell-like gene expression and tumor growth in osteosarcoma (6); and  In addition, SATB2 was found to repress the expression of several Hox genes including Hoxa2, an inhibitor of bone formation and regulator of branchial arch  May 8, 2020 diagnosis, the tumor showed diffuse strong nuclear positivity for SATB2 by immunohistochemistry, supporting the diagnosis of osteosarcoma. Feb 11, 2017 The knowledge regarding the importance of long non-coding RNAs (lncRNAs), a new class of genes, is very sparse in osteosarcoma.
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[Epub ahead of print] Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-Mediated EMT. CONCLUSIONS: SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth.
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However, the molecular mechanisms that regulate OS metastatic spread are largely SATB2 positivity was present in 30/50 (60%) cases lacking osteosarcoma, predominantly as patchy moderate staining within undifferentiated sarcoma. No cases showed SATB2 positivity in chondrosarcoma or rhabdomyosarcoma components.


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Molecular understanding of KRAS- and BRAF - DiVA Portal

Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of Osteosarcoma and Its Variants Osteosarcomas (also known as osteogenic sarcoma) are malignant neoplasms of bone that are composed of proliferating cells that produce osteoid, at least focally.